› 2g59

X-ray diffraction
2.19Å resolution

Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase from Homo sapiens

Released:
DOI: 10.2210/pdb2g59/pdb
PDB entry 2g59 coloured by chain, front view.
PDB entry 2g59 coloured by chain, side view.
PDB entry 2g59 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural genomics of protein phosphatases.
Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK
J Struct Funct Genomics 8 121-40 (2007)
PMID: 18058037

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase O Chains: A, B
Molecule details ›
Chains: A, B
Length: 297 amino acids
Theoretical weight: 34.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16827 (Residues: 914-1200; Coverage: 24%)
Gene names: GLEPP1, PTPRO, PTPU2
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 73.869Å b: 59.723Å c: 76.995Å
α: 90° β: 102.31° γ: 90°
R-values:
R R work R free
0.199 0.199 0.237
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Aiding and abetting roles of NOX oxidases in cellular transformation.
Block et al. (2012)
23 more

6 mentions without citation

Structural genomics of protein phosphatases.
Almo et al. (2007)
5 more