› 2g6f

X-ray diffraction
0.92Å resolution

Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2

Released:
DOI: 10.2210/pdb2g6f/pdb
PDB entry 2g6f coloured by chain, front view.
PDB entry 2g6f coloured by chain, side view.
PDB entry 2g6f coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.
Hoelz A, Janz JM, Lawrie SD, Corwin B, Lee A, Sakmar TP
J Mol Biol 358 509-22 (2006)
PMID: 16527308

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129549 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor 7 Chain: X
Molecule details ›
Chain: X
Length: 59 amino acids
Theoretical weight: 6.73 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O55043 (Residues: 10-63; Coverage: 8%)
Gene names: Arhgef7, Pak3bp, Pixb
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand NCO 1 x NCO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P21212
Unit cell:
a: 73.377Å b: 31.427Å c: 28.171Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.184 0.199
Expression system: Escherichia coli BL21(DE3)

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Citations

7 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
6 more

4 mentions without citation

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
Rouka et al. (2015)
3 more