› 2g8g

X-ray diffraction
3.2Å resolution

Structurally mapping the diverse phenotype of Adeno-Associated Virus serotype 4

Released:
DOI: 10.2210/pdb2g8g/pdb
PDB entry 2g8g coloured by chain, front view.
PDB entry 2g8g coloured by chain, side view.
PDB entry 2g8g coloured by chain, top view.
Source organism: Adeno-associated virus - 4
Primary publication:
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
Govindasamy L, Padron E, McKenna R, Muzyczka N, Kaludov N, Chiorini JA, Agbandje-McKenna M
J Virol 80 11556-70 (2006)
PMID: 16971437

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid Chain: A
Molecule details ›
Chain: A
Length: 524 amino acids
Theoretical weight: 58.44 KDa
Source organism: Adeno-associated virus - 4
Expression system: Escherichia coli
UniProt:
  • Canonical: O41855 (Residues: 211-734; Coverage: 71%)
Sequence domains: Parvovirus coat protein VP2
Structure domains: Parvovirus coat protein VP1/VP2

Ligands and Environments

1 bound ligand:
Ligand D5M 1 x D5M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: I222
Unit cell:
a: 339.6Å b: 319.2Å c: 285Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.263 0.273
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The AAV vector toolkit: poised at the clinical crossroads.
Asokan et al. (2012)
20 more

24 mentions without citation

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry.
Large et al. (2021)
23 more