› 2gal

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE

Released:
DOI: 10.2210/pdb2gal/pdb
PDB entry 2gal coloured by chain, front view.
PDB entry 2gal coloured by chain, side view.
PDB entry 2gal coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the recognition of carbohydrates by human galectin-7.
Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR
Biochemistry 37 13930-40 (1998)
PMID: 9760227

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 135 amino acids
Theoretical weight: 14.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47929 (Residues: 2-136; Coverage: 99%)
Gene names: LGALS7, LGALS7B, PIG1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand GAL 2 x GAL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 54.47Å b: 64.52Å c: 72.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Galectins: structure, function and therapeutic potential.
Yang et al. (2008)
24 more

270 mentions without citation

Mucins in the mucosal barrier to infection.
Linden et al. (2008)
269 more