› 2gcz

Solution NMR

Solution Structure of alpha-Conotoxin OmIA

Released:
DOI: 10.2210/pdb2gcz/pdb
PDB entry 2gcz coloured by chain, ensemble of 20 models, front view.
PDB entry 2gcz coloured by chain, ensemble of 20 models, side view.
PDB entry 2gcz coloured by chain, ensemble of 20 models, top view.
Source organism: Conus omaria
Primary publication:
Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes.
Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH
Biochem Biophys Res Commun 345 248-54 (2006)
PMID: 16678128

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142959 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin OmIA Chain: A
Molecule details ›
Chain: A
Length: 18 amino acids
Theoretical weight: 1.73 KDa
Source organism: Conus omaria
Expression system: Not provided
UniProt:
  • Canonical: P0C1R7 (Residues: 1-17; Coverage: 100%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.
Azam et al. (2009)
9 other articles

7 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
6 more