› 2gd3

Solution NMR

NMR structure of S14G-humanin in 30% TFE solution

Released:
DOI: 10.2210/pdb2gd3/pdb
PDB entry 2gd3 coloured by chain, ensemble of 14 models, front view.
PDB entry 2gd3 coloured by chain, ensemble of 14 models, side view.
PDB entry 2gd3 coloured by chain, ensemble of 14 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.
Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M
Biochem Biophys Res Commun 349 634-42 (2006)
PMID: 16945331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Humanin Chain: A
Molecule details ›
Chain: A
Length: 24 amino acids
Theoretical weight: 2.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8IVG9 (Residues: 1-24; Coverage: 100%)
Gene names: HN, MT-RNR2
Sequence domains: Humanin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing torsion angle dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

Neuroprotective Action of Humanin and Humanin Analogues: Research Findings and Perspectives.
Karachaliou et al. (2023)
11 other articles

1 mention without citation

Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.
Ozgul et al. (2023)