› 2ge2

Solution NMR

Solution structure of the Duplex DNA Containing the 3-(Deoxyguanosin-N2-yl)-2-Acetoaminofluorene

Released:
DOI: 10.2210/pdb2ge2/pdb
PDB entry 2ge2 coloured by chain, front view.
PDB entry 2ge2 coloured by chain, side view.
PDB entry 2ge2 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure and stability of duplex DNA containing the 3-(deoxyguanosin-N2-yl)-2-acetylaminofluorene (dG(N2)-AAF) lesion: a bulky adduct that persists in cellular DNA.
Zaliznyak T, Bonala R, Johnson F, de Los Santos C
Chem Res Toxicol 19 745-52 (2006)
PMID: 16780352

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115293 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*GP*TP*AP*CP*GP*CP*AP*TP*GP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.33 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*CP*AP*TP*GP*CP*GP*TP*AP*CP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand AFF 1 x AFF
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: restrained molecular dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes.
Boer et al. (2009)
2 more

1 mention without citation

Structural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity.
Lior-Hoffmann et al. (2014)