› 2gf5

Solution NMR

Structure of intact FADD (MORT1)

Released:
DOI: 10.2210/pdb2gf5/pdb
PDB entry 2gf5 coloured by chain, ensemble of 25 models, front view.
PDB entry 2gf5 coloured by chain, ensemble of 25 models, side view.
PDB entry 2gf5 coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of FADD and its mode of interaction with procaspase-8.
Carrington PE, Sandu C, Wei Y, Hill JM, Morisawa G, Huang T, Gavathiotis E, Wei Y, Werner MH
Mol Cell 22 599-610 (2006)
PMID: 16762833

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FAS-associated death domain protein Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13158 (Residues: 2-191; Coverage: 91%)
Gene names: FADD, GIG3, MORT1
Sequence domains:
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

27 review citations

The apoptosome: signalling platform of cell death.
Riedl et al. (2007)
26 more

26 mentions without citation

DED or alive: assembly and regulation of the death effector domain complexes.
Riley et al. (2015)
25 more