› 2gi4

Solution NMR

Solution Structure of the Low Molecular Weight Protein Tyrosine Phosphatase from Campylobacter jejuni.

Released:
DOI: 10.2210/pdb2gi4/pdb
PDB entry 2gi4 coloured by chain, ensemble of 10 models, front view.
PDB entry 2gi4 coloured by chain, ensemble of 10 models, side view.
PDB entry 2gi4 coloured by chain, ensemble of 10 models, top view.
Source organism: Campylobacter jejuni
Primary publication:
Three-dimensional structure and ligand interactions of the low molecular weight protein tyrosine phosphatase from Campylobacter jejuni.
Tolkatchev D, Shaykhutdinov R, Xu P, Plamondon J, Watson DC, Young NM, Ni F
Protein Sci 15 2381-94 (2006)
PMID: 17008719

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171025 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphotyrosine protein phosphatase I domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 18 KDa
Source organism: Campylobacter jejuni
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0P8Z8 (Residues: 1-151; Coverage: 100%)
Gene name: Cj1258
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Simulated annealing using torsion angle and Cartesian dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.
Böhmer et al. (2013)
1 more

2 mentions without citation

The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.
Stehle et al. (2012)
1 more