› 2gk9

X-ray diffraction
2.8Å resolution

Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma

Released:
DOI: 10.2210/pdb2gk9/pdb
PDB entry 2gk9 coloured by chain, front view.
PDB entry 2gk9 coloured by chain, side view.
PDB entry 2gk9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Uppenberg J, Hogbom M, Ogg D, Arrowsmith C, Berglund H, Collins R, Ehn M, Flodin S, Flores A, Graslund S, Holmberg-Schiavone L, Edwards A, Hammarstrom M, Kotenyova T, Nilsson-Ehle P, Nordlund P, Nyman T, Persson C, Sagemark J, Stenmark P, Sundstrom M, Thorsell AG, Van Den Berg S, Weigelt J, Hallberg BM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 392 amino acids
Theoretical weight: 44.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TBX8 (Residues: 32-421; Coverage: 93%)
Gene names: PIP4K2C, PIP5K2C
Sequence domains: Phosphatidylinositol-4-phosphate 5-Kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P43
Unit cell:
a: 95.39Å b: 95.39Å c: 189.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.254 0.297
Expression system: Escherichia coli

Quick links