› 2gku

Solution NMR

Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures

Released:
DOI: 10.2210/pdb2gku/pdb
PDB entry 2gku coloured by chain, ensemble of 12 models, front view.
PDB entry 2gku coloured by chain, ensemble of 12 models, side view.
PDB entry 2gku coloured by chain, ensemble of 12 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.
Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ
J Am Chem Soc 128 9963-70 (2006)
PMID: 16866556

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115303 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
Human telomere DNA Chain: A
Molecule details ›
Chain: A
Length: 24 nucleotides
Theoretical weight: 7.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS CARTESIAN DYNAMICS MATRIX RELAXATION
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
35 more

55 mentions without citation

Stability and kinetics of G-quadruplex structures.
Lane et al. (2008)
54 more