› 2glr

X-ray diffraction
2.2Å resolution

MOLECULAR STRUCTURE AT 1.8 ANGSTROMS OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS

Released:
DOI: 10.2210/pdb2glr/pdb
PDB entry 2glr coloured by chain, front view.
PDB entry 2glr coloured by chain, side view.
PDB entry 2glr coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors.
García-Sáez I, Párraga A, Phillips MF, Mantle TJ, Coll M
J Mol Biol 237 298-314 (1994)
PMID: 8145243

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.5 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P19157 (Residues: 2-210; Coverage: 100%)
Gene names: Gstp1, Gstpib
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GTX 2 x GTX
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 101.95Å b: 77.64Å c: 57.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.169 not available
Expression system: Not provided

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Citations

6 review citations

Geometry of nonbonded interactions involving planar groups in proteins.
Chakrabarti et al. (2007)
5 more

1 mention without citation

Binding Direction-Based Two-Dimensional Flattened Contact Area Computing Algorithm for Protein-Protein Interactions.
Kang et al. (2017)