› 2gnn

X-ray diffraction
2.3Å resolution

Crystal Structure of the Orf Virus NZ2 Variant of VEGF-E

Released:
DOI: 10.2210/pdb2gnn/pdb
PDB entry 2gnn coloured by chain, front view.
PDB entry 2gnn coloured by chain, side view.
PDB entry 2gnn coloured by chain, top view.
Source organism: Orf virus (strain NZ2)
Primary publication:
Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
Pieren M, Prota AE, Ruch C, Kostrewa D, Wagner A, Biedermann K, Winkler FK, Ballmer-Hofer K
J Biol Chem 281 19578-87 (2006)
PMID: 16672228

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-156572 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 14.27 KDa
Source organism: Orf virus (strain NZ2)
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P52584 (Residues: 21-133; Coverage: 100%)
Gene name: A2R
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

6 bound ligands:
Ligand CL 3 x CL
Ligand SO4 2 x SO4
Ligand BEN 3 x BEN
Ligand TRS 2 x TRS
Ligand GOL 8 x GOL
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P4122
Unit cell:
a: 98.6Å b: 98.6Å c: 240Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.223 0.247
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

Molecular genetic analysis of orf virus: a poxvirus that has adapted to skin.
Fleming et al. (2015)
4 more

4 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
3 more