› 2goj

X-ray diffraction
2Å resolution

The crystal structure of the enzyme Fe-superoxide dismutase from Plasmodium falciparum

Released:
DOI: 10.2210/pdb2goj/pdb
PDB entry 2goj coloured by chain, front view.
PDB entry 2goj coloured by chain, side view.
PDB entry 2goj coloured by chain, top view.
Source organism: Plasmodium falciparum HB3
Primary publication:
Systematic structural studies of iron superoxide dismutases from human parasites and a statistical coupling analysis of metal binding specificity.
Bachega JF, Navarro MV, Bleicher L, Bortoleto-Bugs RK, Dive D, Hoffmann P, Viscogliosi E, Garratt RC
Proteins 77 26-37 (2009)
PMID: 19384994

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Fe] Chains: A, B
Molecule details ›
Chains: A, B
Length: 197 amino acids
Theoretical weight: 22.63 KDa
Source organism: Plasmodium falciparum HB3
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q27740 (Residues: 2-198; Coverage: 100%)
Gene name: SODB
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FE2 2 x FE2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 55.402Å b: 78.417Å c: 88.369Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.156 0.194
Expression system: Escherichia coli K-12

Quick links

Citations

6 review citations

Superoxide dismutases and superoxide reductases.
Sheng et al. (2014)
5 more

1 mention without citation

Inverse docking based screening and identification of protein targets for Cassiarin alkaloids against Plasmodium falciparum.
Negi et al. (2018)