› 2gom

X-ray diffraction
1.25Å resolution

Crystal structure of Efb-C from Staphylococcus aureus

Released:
DOI: 10.2210/pdb2gom/pdb
PDB entry 2gom coloured by chain, front view.
PDB entry 2gom coloured by chain, side view.
PDB entry 2gom coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus Mu50
Primary publication:
A structural basis for complement inhibition by Staphylococcus aureus.
Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV
Nat Immunol 8 430-7 (2007)
PMID: 17351618

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159505 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrinogen-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 61 amino acids
Theoretical weight: 7.2 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68799 (Residues: 105-165; Coverage: 45%)
Gene names: SAV1158, efb, fib
Sequence domains: Extracellular fibrinogen binding protein C terminal
Structure domains: Sbi, C3 binding domain IV

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43
Unit cell:
a: 59.598Å b: 59.598Å c: 45.634Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

32 review citations

Complement regulators and inhibitory proteins.
Zipfel et al. (2009)
31 more

14 mentions without citation

Complement evasion by human pathogens.
Lambris et al. (2008)
13 more