› 2gtd

X-ray diffraction
2Å resolution

Crystal Structure of a Type III Pantothenate Kinase: Insight into the Catalysis of an Essential Coenzyme A Biosynthetic Enzyme Universally Distributed in Bacteria

Released:
DOI: 10.2210/pdb2gtd/pdb
PDB entry 2gtd coloured by chain, front view.
PDB entry 2gtd coloured by chain, side view.
PDB entry 2gtd coloured by chain, top view.
Source organism: Thermotoga maritima
Primary publication:
Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria.
Yang K, Eyobo Y, Brand LA, Martynowski D, Tomchick D, Strauss E, Zhang H
J Bacteriol 188 5532-40 (2006)
PMID: 16855243

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-194658 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type III pantothenate kinase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 251 amino acids
Theoretical weight: 27.66 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WZY5 (Residues: 1-246; Coverage: 100%)
Gene names: TM_0883, coaX
Sequence domains: Type III pantothenate kinase
Structure domains: Nucleotidyltransferase; domain 5

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 75.112Å b: 137.788Å c: 75.221Å
α: 90° β: 109.23° γ: 90°
R-values:
R R work R free
0.19 0.188 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Coenzyme A biosynthesis: an antimicrobial drug target.
Spry et al. (2008)
2 more

1 mention without citation

Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria.
Yang et al. (2006)