› 2gut

Solution NMR

Solution structure of the trans-activation domain of the human co-activator ARC105

Released:
DOI: 10.2210/pdb2gut/pdb
PDB entry 2gut coloured by chain, ensemble of 15 models, front view.
PDB entry 2gut coloured by chain, ensemble of 15 models, side view.
PDB entry 2gut coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM
Nature 442 700-4 (2006)
PMID: 16799563

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of RNA polymerase II transcription subunit 15 Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RN5 (Residues: 5-78; Coverage: 9%)
Gene names: ARC105, CTG7A, MED15, PCQAP, TIG1, TNRC7
Sequence domains: ARC105/Med15 mediator subunit N-terminal KIX domain
Structure domains: Coactivator CBP, KIX domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing using CYANA
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

75 review citations

Cellular cholesterol trafficking and compartmentalization.
Ikonen E. (2008)
74 more

4 mentions without citation

Twenty years of Mediator complex structural studies.
Verger et al. (2019)
3 more