› 2h0n

X-ray diffraction
1.53Å resolution

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC

Released:
DOI: 10.2210/pdb2h0n/pdb
PDB entry 2h0n coloured by chain, front view.
PDB entry 2h0n coloured by chain, side view.
PDB entry 2h0n coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC.
Robeyns K, Herdewijn P, Van Meervelt L
J Am Chem Soc 130 1979-84 (2008)
PMID: 18198873

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115320 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-(*(XGL)P*(XTL)P*(XGL)P*(XTL)P*(XAL)P*(XCL)P*(XAL)P*(XCL)-Phosphate)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 8 nucleotides
Theoretical weight: 2.51 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 2HP 2 x 2HP
4 modified residues:
Ligand XGL 4 x XGL
Ligand XTL 4 x XTL
Ligand XAL 4 x XAL
Ligand XCL 4 x XCL

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: R32
Unit cell:
a: 41.455Å b: 41.455Å c: 65.58Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.158 not available
Expression system: Not provided

Quick links

Citations

3 review citations

Chemical modification of oligonucleotides for therapeutic, bioanalytical and other applications.
Bell et al. (2009)
2 more

2 mentions without citation

The structural diversity of artificial genetic polymers.
Anosova et al. (2016)
1 more