› 2h2w

X-ray diffraction
2.52Å resolution

Crystal structure of Homoserine O-succinyltransferase (EC 2.3.1.46) (Homoserine O-transsuccinylase) (HTS) (tm0881) from THERMOTOGA MARITIMA at 2.52 A resolution

Released:
DOI: 10.2210/pdb2h2w/pdb
PDB entry 2h2w coloured by chain, front view.
PDB entry 2h2w coloured by chain, side view.
PDB entry 2h2w coloured by chain, top view.
Source organism: Thermotoga maritima
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homoserine O-acetyltransferase Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 36.77 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WZY3 (Residues: 1-300; Coverage: 99%)
Gene names: TM_0881, metA, metAA
Sequence domains: Homoserine O-succinyltransferase
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3121
Unit cell:
a: 72.609Å b: 72.609Å c: 126.913Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.19 0.274
Expression system: Escherichia coli

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