› 2h4c

X-ray diffraction
2.6Å resolution

Structure of Daboiatoxin (heterodimeric PLA2 venom)

Released:
DOI: 10.2210/pdb2h4c/pdb
PDB entry 2h4c coloured by chain, front view.
PDB entry 2h4c coloured by chain, side view.
PDB entry 2h4c coloured by chain, top view.
Source organism: Daboia siamensis
Primary publication:
Structural and pharmacological comparison of daboiatoxin from Daboia russelli siamensis with viperotoxin F and vipoxin from other vipers.
Gopalan G, Thwin MM, Gopalakrishnakone P, Swaminathan K
Acta Crystallogr D Biol Crystallogr 63 722-9 (2007)
PMID: 17505111

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-182007 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acidic phospholipase A2 daboiatoxin A chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 122 amino acids
Theoretical weight: 13.63 KDa
Source organism: Daboia siamensis
UniProt:
  • Canonical: Q7T2R1 (Residues: 17-138; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain
Acidic phospholipase A2 daboiatoxin B chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 122 amino acids
Theoretical weight: 14.04 KDa
Source organism: Daboia siamensis
UniProt:
  • Canonical: Q7T3T5 (Residues: 9-130; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P32
Unit cell:
a: 66.977Å b: 66.977Å c: 240.273Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.22 0.307

Quick links

Citations

6 citation in other articles

Effects of phospholipase A2 and metalloprotease fractions of Russell's viper venom on cytokines and renal hemodynamics in dogs.
Mitrmoonpitak et al. (2013)
5 more

2 mentions without citation

Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High-Valent Intermediates, and Related Model Complexes.
Jasniewski et al. (2018)
1 more