› 2h4t

X-ray diffraction
1.9Å resolution

Crystal structure of rat carnitine palmitoyltransferase II

Released:
DOI: 10.2210/pdb2h4t/pdb
PDB entry 2h4t coloured by chain, front view.
PDB entry 2h4t coloured by chain, side view.
PDB entry 2h4t coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).
Hsiao YS, Jogl G, Esser V, Tong L
Biochem Biophys Res Commun 346 974-80 (2006)
PMID: 16781677

Function and Biology Details

Reaction catalysed: 
Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carnitine O-palmitoyltransferase 2, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 626 amino acids
Theoretical weight: 70.72 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18886 (Residues: 32-656; Coverage: 95%)
Gene names: Cpt-2, Cpt2
Sequence domains: Choline/Carnitine o-acyltransferase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand D12 6 x D12
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 73.77Å b: 73.8Å c: 90.56Å
α: 70.65° β: 73.62° γ: 88.06°
R-values:
R R work R free
0.189 0.189 0.221
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structural insight into function and regulation of carnitine palmitoyltransferase.
Rufer et al. (2009)
2 more

6 mentions without citation

Monotopic Membrane Proteins Join the Fold.
Allen et al. (2019)
5 more