› 2h7b

Solution NMR

Solution structure of the eTAFH domain from the human leukemia-associated fusion protein AML1-ETO

Released:
DOI: 10.2210/pdb2h7b/pdb
PDB entry 2h7b coloured by chain, ensemble of 20 models, front view.
PDB entry 2h7b coloured by chain, ensemble of 20 models, side view.
PDB entry 2h7b coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain.
Plevin MJ, Zhang J, Guo C, Roeder RG, Ikura M
Proc Natl Acad Sci U S A 103 10242-10247 (2006)
PMID: 16803958

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06455 (Residues: 120-222; Coverage: 17%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: NHR1 homology to TAF
Structure domains: TAFH/NHR1 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Molecular mechanisms of ETS transcription factor-mediated tumorigenesis.
Kar et al. (2013)
8 more

5 mentions without citation

Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators.
Wang et al. (2007)
4 more