Function and Biology Details
Reaction catalysed:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase I
- DNA topoisomerase I, catalytic core, eukaryotic-type
- DNA topoisomerase I, N-terminal domain superfamily
- DNA topoisomerase IB, active site
- DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
- DNA breaking-rejoining enzyme, catalytic core
- DNA topoisomerase I, N-terminal, viral
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
DNA topoisomerase 1 and DNA (preferred)
PDBe Complex ID:
PDB-CPX-115327 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
DNA topoisomerase 1
Molecule details ›
P32989Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
C2221
Expression systems:
- Escherichia coli BL21(DE3)
- Not provided
