› 2h7w

X-ray diffraction
1.7Å resolution

Crystal structure of Chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi

Released:
DOI: 10.2210/pdb2h7w/pdb
PDB entry 2h7w coloured by chain, front view.
PDB entry 2h7w coloured by chain, side view.
PDB entry 2h7w coloured by chain, top view.
Source organism: Trypanosoma cruzi
Primary publication:
Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi.
Figueiredo da Silva AA, de Carvalho Vieira L, Krieger MA, Goldenberg S, Zanchin NI, Guimarães BG
J Struct Biol 157 416-23 (2007)
PMID: 17011790

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chagasin Chains: A, B
Molecule details ›
Chains: A, B
Length: 131 amino acids
Theoretical weight: 14.48 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
  • Canonical: Q966X9 (Residues: 1-110; Coverage: 100%)
Gene name: cha
Sequence domains: Chagasin family peptidase inhibitor I42
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P3112
Unit cell:
a: 48.779Å b: 48.779Å c: 183.602Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.205 0.238
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway.
Scharfstein et al. (2008)
1 more

1 mention without citation

A Coarse-Grained Methodology Identifies Intrinsic Mechanisms That Dissociate Interacting Protein Pairs.
Abdizadeh et al. (2020)