Function and Biology Details
Reactions catalysed:
Malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CoA + 6 CO(2) + 5 NADP(+) + 2 H(2)O
Malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH = narbonolide + 7 CoA + 7 CO(2) + 5 NADP(+) + 2 H(2)O
Biochemical function:
- not assigned
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assemblies composition:
Assembly name:
PDBe Complex ID:
PDB-CPX-195647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Narbonolide/10-deoxymethynolide synthase PikA4, module 6
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 33.79 KDa
Source organism: Streptomyces venezuelae
Expression system: Escherichia coli
UniProt:
Sequence domains: Thioesterase domain
Structure domains: alpha/beta hydrolase
Length: 319 amino acids
Theoretical weight: 33.79 KDa
Source organism: Streptomyces venezuelae
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9ZGI2 (Residues: 1049-1346; Coverage: 22%)
Sequence domains: Thioesterase domain
Structure domains: alpha/beta hydrolase
