› 2h8a

Electron crystallography
3.2Å resolution

Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione

Released:
DOI: 10.2210/pdb2h8a/pdb
PDB entry 2h8a coloured by chain, front view.
PDB entry 2h8a coloured by chain, side view.
PDB entry 2h8a coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for detoxification and oxidative stress protection in membranes.
Holm PJ, Bhakat P, Jegerschöld C, Gyobu N, Mitsuoka K, Fujiyoshi Y, Morgenstern R, Hebert H
J Mol Biol 360 934-45 (2006)
PMID: 16806268

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139888 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microsomal glutathione S-transferase 1 Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.36 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P08011 (Residues: 2-155; Coverage: 99%)
Gene names: Gst12, Mgst1
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å

Quick links

Citations

21 review citations

Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes.
Deponte M. (2013)
20 more

13 mentions without citation

Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.
Smith et al. (2011)
12 more