› 2h8s

Solution NMR

Solution structure of alpha-conotoxin Vc1.1

Released:
DOI: 10.2210/pdb2h8s/pdb
PDB entry 2h8s coloured by chain, ensemble of 20 models, front view.
PDB entry 2h8s coloured by chain, ensemble of 20 models, side view.
PDB entry 2h8s coloured by chain, ensemble of 20 models, top view.
Source organism: Conus victoriae
Primary publication:
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.
Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ
J Biol Chem 281 23254-63 (2006)
PMID: 16754662

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159651 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin Vc1a Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.81 KDa
Source organism: Conus victoriae
Expression system: Not provided
UniProt:
  • Canonical: P69747 (Residues: 50-65; Coverage: 39%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

29 review citations

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
Taly et al. (2009)
28 more

15 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
14 more