› 2h95

Solid-state NMR

Structure of the Amantadine-Blocked Influenza A M2 Proton Channel Trans-membrane Domain by Solid-state NMR spectroscopy

Released:
DOI: 10.2210/pdb2h95/pdb
PDB entry 2h95 coloured by chain, front view.
PDB entry 2h95 coloured by chain, side view.
PDB entry 2h95 coloured by chain, top view.
Source organism: Influenza A virus (A/USSR/90/1977(H1N1))
Primary publication:
Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus.
Hu J, Asbury T, Achuthan S, Li C, Bertram R, Quine JR, Fu R, Cross TA
Biophys J 92 4335-43 (2007)
PMID: 17384070

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 18 amino acids
Theoretical weight: 1.96 KDa
Source organism: Influenza A virus (A/USSR/90/1977(H1N1))
Expression system: Not provided
UniProt:
  • Canonical: Q3LZC0 (Residues: 17-34; Coverage: 45%)
Gene name: M
Sequence domains: Influenza Matrix protein (M2)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: ENERGY MINIMIZATION WITH ORIENTATIONAL CONSTRAINTS
Expression system: Not provided

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Citations

26 review citations

Structures of influenza A proteins and insights into antiviral drug targets.
Das et al. (2010)
25 more

18 mentions without citation

Influence of solubilizing environments on membrane protein structures.
Cross et al. (2011)
17 more