› 2ha8

X-ray diffraction
1.6Å resolution

Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1

Released:
DOI: 10.2210/pdb2ha8/pdb
PDB entry 2ha8 coloured by chain, front view.
PDB entry 2ha8 coloured by chain, side view.
PDB entry 2ha8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min J, Wu H, Zeng H, Loppnau P, Battaile K, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171661 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable methyltransferase TARBP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13395 (Residues: 1438-1621; Coverage: 11%)
Gene names: TARBP1, TRM3, TRP185
Sequence domains: SpoU rRNA Methylase family
Structure domains: Alpha/beta knot

Ligands and Environments

1 bound ligand:
Ligand SAH 2 x SAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 41.237Å b: 86.93Å c: 48.266Å
α: 90° β: 100.85° γ: 90°
R-values:
R R work R free
0.178 0.177 0.209
Expression system: Escherichia coli

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