› 2haz

X-ray diffraction
1.7Å resolution

Crystal structure of the first fibronectin domain of human NCAM1

Released:
DOI: 10.2210/pdb2haz/pdb
PDB entry 2haz coloured by chain, front view.
PDB entry 2haz coloured by chain, side view.
PDB entry 2haz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation.
Mendiratta SS, Sekulic N, Hernandez-Guzman FG, Close BE, Lavie A, Colley KJ
J Biol Chem 281 36052-9 (2006)
PMID: 17003032

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural cell adhesion molecule 1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13591 (Residues: 508-608; Coverage: 12%)
Gene names: NCAM, NCAM1
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2221
Unit cell:
a: 42.76Å b: 53.88Å c: 74.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.212 0.286
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.
Rutishauser U. (2008)
9 more

9 mentions without citation

Transport-related structures and processes of the nuclear pore complex studied through molecular dynamics.
Miao et al. (2009)
8 more