2hey

X-ray diffraction
2Å resolution

Crystal structure of murine OX40L bound to human OX40

Released:
Source organisms:
Primary publication:
The crystal structure of the costimulatory OX40-OX40L complex.
Structure 14 1321-30 (2006)
PMID: 16905106

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-155075 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 4 Chains: F, G
Molecule details ›
Chains: F, G
Length: 152 amino acids
Theoretical weight: 17.06 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43488 (Residues: 51-198; Coverage: 75%)
Gene names: Ox40l, Tnfsf4, Txgp1l
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 4 Chains: R, T
Molecule details ›
Chains: R, T
Length: 146 amino acids
Theoretical weight: 15.81 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43489 (Residues: 29-170; Coverage: 57%)
Gene names: TNFRSF4, TXGP1L
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: R32
Unit cell:
a: 104.729Å b: 104.729Å c: 478.161Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.221 0.247
Expression system: Spodoptera frugiperda