› 2hh7

X-ray diffraction
2.55Å resolution

Crystal Structure of Cu(I) bound CsoR from Mycobacterium tuberculosis.

Released:
DOI: 10.2210/pdb2hh7/pdb
PDB entry 2hh7 coloured by chain, front view.
PDB entry 2hh7 coloured by chain, side view.
PDB entry 2hh7 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Liu T, Ramesh A, Ma Z, Ward SK, Zhang L, George GN, Talaat AM, Sacchettini JC, Giedroc DP
Nat Chem Biol 3 60-8 (2007)
PMID: 17143269

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-161923 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-sensing transcriptional repressor CsoR Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.82 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WP49 (Residues: 1-119; Coverage: 100%)
Gene names: Rv0967, croR, csoR
Sequence domains: Metal-sensitive transcriptional repressor
Structure domains: Metal-sensitive repressor, helix protomer

Ligands and Environments

1 bound ligand:
Ligand CU1 1 x CU1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6422
Unit cell:
a: 91.059Å b: 91.059Å c: 46.779Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.231 0.279
Expression system: Escherichia coli

Quick links

Citations

54 review citations

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.
Djoko et al. (2015)
53 more

12 mentions without citation

Coordination chemistry of bacterial metal transport and sensing.
Ma et al. (2009)
11 more