› 2hi9

X-ray diffraction
2.3Å resolution

Crystal Structure of human native protein C inhibitor

Released:
DOI: 10.2210/pdb2hi9/pdb
PDB entry 2hi9 coloured by chain, front view.
PDB entry 2hi9 coloured by chain, side view.
PDB entry 2hi9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of native protein C inhibitor provides insight into its multiple functions.
Li W, Adams TE, Kjellberg M, Stenflo J, Huntington JA
J Biol Chem 282 13759-68 (2007)
PMID: 17337440

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma serine protease inhibitor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 363 amino acids
Theoretical weight: 40.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05154 (Residues: 44-406; Coverage: 94%)
Gene names: PCI, PLANH3, PROCI, SERPINA5
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CIT 3 x CIT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: C2
Unit cell:
a: 198.59Å b: 70.95Å c: 123.88Å
α: 90° β: 127.92° γ: 90°
R-values:
R R work R free
0.229 0.227 0.269
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Thrombin inhibition by the serpins.
Huntington JA. (2013)
4 more

7 mentions without citation

Serpins in thrombosis, hemostasis and fibrinolysis.
Rau et al. (2007)
6 more