› 2hqo

Solution NMR

Structure of a Atypical Orphan Response Regulator Protein Revealed a New Phosphorylation-Independent Regulatory Mechanism

Released:
DOI: 10.2210/pdb2hqo/pdb
PDB entry 2hqo coloured by chain, ensemble of 20 models, front view.
PDB entry 2hqo coloured by chain, ensemble of 20 models, side view.
PDB entry 2hqo coloured by chain, ensemble of 20 models, top view.
Source organism: Helicobacter pylori J99
Primary publication:
Structure of an atypical orphan response regulator protein supports a new phosphorylation-independent regulatory mechanism.
Hong E, Lee HM, Ko H, Kim DU, Jeon BY, Jung J, Shin J, Lee SA, Kim Y, Jeon YH, Cheong C, Cho HS, Lee W
J Biol Chem 282 20667-75 (2007)
PMID: 17491010

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TRANSCRIPTIONAL REGULATOR Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 13.88 KDa
Source organism: Helicobacter pylori J99
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ZM42 (Residues: 1-119; Coverage: 53%)
Gene name: jhp_0381
Sequence domains: Response regulator receiver domain
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Receiver domain structure and function in response regulator proteins.
Bourret RB. (2010)
8 more

1 mention without citation

NMR study on small proteins from Helicobacter pylori for antibiotic target discovery: a review.
Kang et al. (2013)