› 2hri

X-ray diffraction
2.09Å resolution

A parallel stranded human telomeric quadruplex in complex with the porphyrin TMPyP4

Released:
DOI: 10.2210/pdb2hri/pdb
PDB entry 2hri coloured by chain, front view.
PDB entry 2hri coloured by chain, side view.
PDB entry 2hri coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for binding of porphyrin to human telomeres.
Parkinson GN, Ghosh R, Neidle S
Biochemistry 46 2390-7 (2007)
PMID: 17274602

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115361 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 11 nucleotides
Theoretical weight: 3.47 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 3 x K
Ligand POH 2 x POH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2221
Unit cell:
a: 37.29Å b: 61.99Å c: 61.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.248
Expression system: Not provided

Quick links

Citations

21 review citations

A hitchhiker's guide to G-quadruplex ligands.
Monchaud et al. (2008)
20 more

13 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
12 more