› 2hts

X-ray diffraction
1.83Å resolution

CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF THE HEAT SHOCK TRANSCRIPTION FACTOR

Released:
DOI: 10.2210/pdb2hts/pdb
PDB entry 2hts coloured by chain, front view.
PDB entry 2hts coloured by chain, side view.
PDB entry 2hts coloured by chain, top view.
Source organism: Kluyveromyces lactis
Primary publication:
Crystal structure of the DNA binding domain of the heat shock transcription factor.
Harrison CJ, Bohm AA, Nelson HC
Science 263 224-7 (1994)
PMID: 8284672

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149528 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock transcription factor Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.95 KDa
Source organism: Kluyveromyces lactis
Expression system: Not provided
UniProt:
  • Canonical: P22121 (Residues: 193-281; Coverage: 13%)
Gene names: HSF, KLLA0D03322g
Sequence domains: HSF-type DNA-binding
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

1 bound ligand:
Ligand ACY 2 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 36.8Å b: 34.3Å c: 67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.248
Expression system: Not provided

Quick links

Citations

30 review citations

Heat shock factors: integrators of cell stress, development and lifespan.
Akerfelt et al. (2010)
29 more

5 mentions without citation

Fungal Skn7 stress responses and their relationship to virulence.
Fassler et al. (2011)
4 more