We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 2hui

X-ray diffraction
1.75Å resolution

Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid

Released:
DOI: 10.2210/pdb2hui/pdb
Model geometry
Fit model/data
PDB entry 2hui coloured by chain, front view.
PDB entry 2hui coloured by chain, side view.
PDB entry 2hui coloured by chain, top view.
Source organism: Aedes aegypti
Primary publication:
Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase.
Han Q, Robinson H, Gao YG, Vogelaar N, Wilson SR, Rizzi M, Li J
J Biol Chem 281 37175-82 (2006)
PMID: 16990263

Function and Biology Details

Reaction catalysed: 
glyoxylate + L-alanine = glycine + pyruvate.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174734 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alanine--glyoxylate aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 393 amino acids
Theoretical weight: 43.39 KDa
Source organism: Aedes aegypti
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q3LSM4 (Residues: 1-393; Coverage: 100%)
Gene names: AAEL010480, AGT
Sequence domains: Aminotransferase class-V
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GLV 2 x GLV
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X25
Spacegroup: R3
Unit cell:
a: 137.082Å b: 137.082Å c: 120.425Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.175 0.206
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.
Han et al. (2010)
3 more