› 2hwk

X-ray diffraction
2.45Å resolution

Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain

Released:
DOI: 10.2210/pdb2hwk/pdb
PDB entry 2hwk coloured by chain, front view.
PDB entry 2hwk coloured by chain, side view.
PDB entry 2hwk coloured by chain, top view.
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Primary publication:
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
Russo AT, White MA, Watowich SJ
Structure 14 1449-58 (2006)
PMID: 16962975

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
helicase nsP2 Chain: A
Molecule details ›
Chain: A
Length: 320 amino acids
Theoretical weight: 36.24 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WIJ1 (Residues: 1003-1322; Coverage: 17%)
Gene name: NS
Sequence domains: Peptidase family C9
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: P212121
Unit cell:
a: 47.47Å b: 72.58Å c: 106.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.192 0.242
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy.
Thiberville et al. (2013)
10 more

16 mentions without citation

Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.
Abu Bakar et al. (2018)
15 more