› 2i0o

X-ray diffraction
1.7Å resolution

Crystal structure of Anopheles gambiae Ser/Thr phosphatase complexed with Zn2+

Released:
DOI: 10.2210/pdb2i0o/pdb
PDB entry 2i0o coloured by chain, front view.
PDB entry 2i0o coloured by chain, side view.
PDB entry 2i0o coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
Structural genomics of protein phosphatases.
Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK
J Struct Funct Genomics 8 121-40 (2007)
PMID: 18058037

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-181870 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PPM-type phosphatase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 33.26 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7PP01 (Residues: 2-578; Coverage: 45%)
Gene name: AgaP_AGAP006171
Sequence domains: Protein phosphatase 2C
Structure domains: PPM-type phosphatase domain

Ligands and Environments

1 bound ligand:
Ligand ZN 6 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 64.109Å b: 84.572Å c: 108.279Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.235
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

24 review citations

Aiding and abetting roles of NOX oxidases in cellular transformation.
Block et al. (2012)
23 more

4 mentions without citation

Structural genomics of protein phosphatases.
Almo et al. (2007)
3 more