› 2i1p

Solution NMR

Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin

Released:
DOI: 10.2210/pdb2i1p/pdb
PDB entry 2i1p coloured by chain, ensemble of 20 models, front view.
PDB entry 2i1p coloured by chain, ensemble of 20 models, side view.
PDB entry 2i1p coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin.
Wolf CA, Dancea F, Shi M, Bade-Noskova V, Rüterjans H, Kerjaschki D, Lücke C
J Biomol NMR 37 321-8 (2007)
PMID: 17245526

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 48 amino acids
Theoretical weight: 5.1 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P98158 (Residues: 1185-1229; Coverage: 1%)
Gene name: Lrp2
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 49%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Endocytic receptors in the renal proximal tubule.
Christensen et al. (2012)
1 more

2 mentions without citation

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil et al. (2013)
1 more