› 2i3z

X-ray diffraction
2.9Å resolution

rat DPP-IV with xanthine mimetic inhibitor #7

Released:
DOI: 10.2210/pdb2i3z/pdb
PDB entry 2i3z coloured by chain, front view.
PDB entry 2i3z coloured by chain, side view.
PDB entry 2i3z coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL, Lubben TW, Ballaron SJ, Sham HL, von Geldern TW
Bioorg. Med. Chem. Lett. 16 6226-30 (2006)
PMID: 17010607

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-147060 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 730 amino acids
Theoretical weight: 84.34 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P14740 (Residues: 38-767; Coverage: 95%)
Gene names: Cd26, Dpp4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LIR 1 x LIR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P213
Unit cell:
a: 207.293Å b: 207.293Å c: 207.293Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.253 0.29

Quick links

Citations

6 citation in other articles

3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors.
Eckhardt et al. (2008)
5 more