› 2i44

X-ray diffraction
2.04Å resolution

Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii

Released:
DOI: 10.2210/pdb2i44/pdb
PDB entry 2i44 coloured by chain, front view.
PDB entry 2i44 coloured by chain, side view.
PDB entry 2i44 coloured by chain, top view.
Source organism: Toxoplasma gondii
Primary publication:
Structural genomics of protein phosphatases.
Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK
J Struct Funct Genomics 8 121-40 (2007)
PMID: 18058037

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186675 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PPM-type phosphatase domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 324 amino acids
Theoretical weight: 36.63 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WPN9 (Residues: 10-331; Coverage: 97%)
Gene name: TGRH88_075910
Sequence domains: Protein phosphatase 2C
Structure domains: PPM-type phosphatase domain

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
1 modified residue:
Ligand MSE 42 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 96.4Å b: 192.96Å c: 61.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.244
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Aiding and abetting roles of NOX oxidases in cellular transformation.
Block et al. (2012)
23 more

4 mentions without citation

Structural genomics of protein phosphatases.
Almo et al. (2007)
3 more