› 2i55

X-ray diffraction
2.9Å resolution

Complex of glucose-1,6-bisphosphate with phosphomannomutase from Leishmania mexicana

Released:
DOI: 10.2210/pdb2i55/pdb
Model geometry
Fit model/data
PDB entry 2i55 coloured by chain, front view.
PDB entry 2i55 coloured by chain, side view.
PDB entry 2i55 coloured by chain, top view.
Source organism: Leishmania mexicana
Primary publication:
Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms.
Kedzierski L, Malby RL, Smith BJ, Perugini MA, Hodder AN, Ilg T, Colman PM, Handman E
J Mol Biol 363 215-27 (2006)
PMID: 16963079

Function and Biology Details

Reaction catalysed: 
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphomannomutase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 247 amino acids
Theoretical weight: 28.12 KDa
Source organism: Leishmania mexicana
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q95ZD7 (Residues: 1-247; Coverage: 100%)
Gene name: pmm
Sequence domains: Eukaryotic phosphomannomutase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand MG 5 x MG
Ligand B16 2 x B16
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: P3121
Unit cell:
a: 92.224Å b: 92.224Å c: 172.824Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.268
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.
Nagle et al. (2014)
2 more

7 mentions without citation

Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.
da Trindade et al. (2018)
6 more