› 2i65

X-ray diffraction
1.9Å resolution

Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis

Released:
DOI: 10.2210/pdb2i65/pdb
PDB entry 2i65 coloured by chain, front view.
PDB entry 2i65 coloured by chain, side view.
PDB entry 2i65 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q
J Biol Chem 281 32861-9 (2006)
PMID: 16951430

Function and Biology Details

Reactions catalysed: 
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 262 amino acids
Theoretical weight: 30.38 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAD 2 x NAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P1
Unit cell:
a: 41.451Å b: 50.715Å c: 65.2Å
α: 108.76° β: 92.01° γ: 96.38°
R-values:
R R work R free
0.199 0.194 0.229
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.
Lee HC. (2012)
7 more

7 mentions without citation

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Wesolowski et al. (2009)
6 more