› 2ibb

X-ray diffraction
2.4Å resolution

Crystal Structure of the First and Second FNIII Domains of Ihog

Released:
DOI: 10.2210/pdb2ibb/pdb
PDB entry 2ibb coloured by chain, front view.
PDB entry 2ibb coloured by chain, side view.
PDB entry 2ibb coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure of a heparin-dependent complex of Hedgehog and Ihog.
McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ
Proc Natl Acad Sci U S A 103 17208-13 (2006)
PMID: 17077139

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194278 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interference hedgehog Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 24.16 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VM64 (Residues: 466-676; Coverage: 24%)
Gene names: CG9211, ihog
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 39.38Å b: 65.24Å c: 84.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.244 0.275
Expression system: Escherichia coli

Quick links

Citations

16 review citations

The mechanisms of Hedgehog signalling and its roles in development and disease.
Briscoe et al. (2013)
15 more

4 mentions without citation

Structure of a heparin-dependent complex of Hedgehog and Ihog.
McLellan et al. (2006)
3 more