Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Immunoglobulin-like fold
- Immunoglobulin V-set domain
- VSIG4, immunoglobulin variable (IgV)-like domain
- Netrin module, non-TIMP type
- Tissue inhibitor of metalloproteinases-like, OB-fold
- Alpha-macroglobulin, receptor-binding
- Alpha-macroglobulin, receptor-binding domain superfamily
- Immunoglobulin subtype
11 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133826 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Complement C3 beta chain
Molecule details ›
Chains: A, D
Length: 642 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 642 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P01024 (Residues: 23-664; Coverage: 39%)
Sequence domains:
- Macroglobulin domain MG1
- MG2 domain
- Macroglobulin domain MG3
- Macroglobulin domain MG4
- Alpha-2-macroglobulin bait region domain
Complement C3c alpha' chain fragment 1
Molecule details ›
Chains: B, E
Length: 206 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 206 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 749-954; Coverage: 13%)
Sequence domains:
Structure domains:
Complement C3c alpha' chain fragment 2
Molecule details ›
Chains: C, F
Length: 343 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 343 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 1321-1663; Coverage: 21%)
Sequence domains:
Structure domains:
V-set and immunoglobulin domain-containing protein 4
Molecule details ›
Chains: S, T
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9Y279 (Residues: 19-137; Coverage: 31%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
