› 2if5

X-ray diffraction
2Å resolution

Structure of the POZ domain of human LRF, a master regulator of oncogenesis

Released:
DOI: 10.2210/pdb2if5/pdb
PDB entry 2if5 coloured by chain, front view.
PDB entry 2if5 coloured by chain, side view.
PDB entry 2if5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the POZ domain of human LRF, a master regulator of oncogenesis.
Schubot FD, Tropea JE, Waugh DS
Biochem Biophys Res Commun 351 1-6 (2006)
PMID: 17052694

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger and BTB domain-containing protein 7A Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 12.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95365 (Residues: 9-128; Coverage: 21%)
Gene names: FBI1, LRF, ZBTB7, ZBTB7A, ZNF857A
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:
Ligand PR 3 x PR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I4122
Unit cell:
a: 65.85Å b: 65.85Å c: 162.603Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.229 0.291
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.
Lee et al. (2012)
20 other articles

4 mentions without citation

Structure of the human Nac1 POZ domain.
Stead et al. (2009)
3 more