› 2iip

X-ray diffraction
2.05Å resolution

Human Nicotinamide N-methyltransferase

Released:
DOI: 10.2210/pdb2iip/pdb
PDB entry 2iip coloured by chain, front view.
PDB entry 2iip coloured by chain, side view.
PDB entry 2iip coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bernstein G, Min J, Wu H, Tempel W, Zeng H, Loppnau P, Avvakumov GV, Wasney G, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide N-methyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 283 amino acids
Theoretical weight: 31.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40261 (Residues: 1-264; Coverage: 100%)
Gene name: NNMT
Sequence domains: NNMT/PNMT/TEMT family
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments


Cofactor: Ligand SAH 4 x SAH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 46.016Å b: 62.007Å c: 107.073Å
α: 82.35° β: 81.89° γ: 68.3°
R-values:
R R work R free
0.219 0.217 0.265
Expression system: Escherichia coli

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