Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Ran-GTPase activating protein 1, C-terminal domain superfamily
- Ubiquitin-like domain
- Ulp1 protease family, C-terminal catalytic domain
- Ran-GTPase activating protein 1, C-terminal
- Rad60/SUMO-like domain
- Small ubiquitin-related modifier 1, Ubl domain
- Ubiquitin-like domain superfamily
- Papain-like cysteine peptidase superfamily
Structure analysis Details
Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-155414 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sentrin-specific protease 2
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 27.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ulp1 protease family, C-terminal catalytic domain
Structure domains: Adenoviral Proteinase; Chain A
Length: 232 amino acids
Theoretical weight: 27.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9HC62 (Residues: 364-589; Coverage: 38%)
Sequence domains: Ulp1 protease family, C-terminal catalytic domain
Structure domains: Adenoviral Proteinase; Chain A
Small ubiquitin-related modifier 1
Molecule details ›
Chain: B
Length: 82 amino acids
Theoretical weight: 9.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 82 amino acids
Theoretical weight: 9.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P63165 (Residues: 18-97; Coverage: 79%)
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Ran GTPase-activating protein 1
Molecule details ›
Chain: C
Length: 172 amino acids
Theoretical weight: 18.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: RanGAP1 C-terminal domain
Structure domains: Ran-GTPase activating protein 1, C-terminal domain
Length: 172 amino acids
Theoretical weight: 18.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P46060 (Residues: 418-587; Coverage: 29%)
Sequence domains: RanGAP1 C-terminal domain
Structure domains: Ran-GTPase activating protein 1, C-terminal domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 31-ID
Spacegroup:
P6422
Expression system: Escherichia coli
