› 2irt

X-ray diffraction
3.2Å resolution

INITIAL CRYSTALLOGRAPHIC ANALYSES OF A RECOMBINANT INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN

Released:
DOI: 10.2210/pdb2irt/pdb
PDB entry 2irt coloured by chain, front view.
PDB entry 2irt coloured by chain, side view.
PDB entry 2irt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Initial crystallographic analysis of a recombinant human interleukin-1 receptor antagonist protein.
Clancy LL, Finzel BC, Yem AW, Deibel MR, Strakalaitis NA, Brunner DP, Sweet RM, Einspahr HM
Acta Crystallogr D Biol Crystallogr 50 197-201 (1994)
PMID: 15299459

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor antagonist protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 152 amino acids
Theoretical weight: 17.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18510 (Residues: 26-177; Coverage: 100%)
Gene names: IL1F3, IL1RA, IL1RN
Sequence domains: Interleukin-1 / 18

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 72.35Å b: 72.35Å c: 114.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.44 0.44 not available
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline.
Schreuder et al. (1995)

1 mention without citation

Robust automated backbone triple resonance NMR assignments of proteins using Bayesian-based simulated annealing.
Bishop et al. (2023)